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Special care is indicated in patients who have experienced an allergic or anaphylactic reaction to penicillin or other beta-lactams. As with other antibiotics, prolonged use of Cefuroxime may result in overgrowth of non-susceptible organisms (eg. Candida, Enterococci, Clostridium difficile), which may require interruption of treatment.
Tablet and Oral suspension: Pseudomembranous colitis has been reported with the use of broad-spectrum antibiotics; therefore, it is important to consider its diagnosis in patients who develop serious diarrhea during or after antibiotic use.
Effects on Ability to Drive and Use Machines: As this medicine may cause dizziness, patients should be warned to be cautious when driving or operating machinery.
Capsule: Cephalosporin antibiotics may in general be given safely to patients who are hypersensitive to penicillins, although cross-reactions have been reported. Cephalosporin antibiotics at high dosage should be given with caution to patients receiving concurrent treatment with potent diuretics such as frusemide, as these combinations are suspected of adversely affecting renal function. Clinical experience with Cefuroxime has shown that this is not likely to be a problem at the recommended dose levels.
Tablet: With a sequential therapy regime the timing of change to oral therapy is determined by severity of the infection, clinical status of the patient and susceptibility of the pathogens involved. If there is no clinical improvement within 72 hours, then the parenteral course of treatment must be continued. Refer to the relevant prescribing information for cefuroxime sodium before initiating sequential therapy.
