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The usual course of therapy is seven days (range 5 to 10 days).
Cefuroxime axetil should be taken after food for optimum absorption.
Dosage in adults: Most infections: 250 mg twice daily.
Urinary tract infections: 125 mg or 250 mg twice daily.
Mild to moderate lower respiratory tract infections e.g. bronchitis: 250 mg twice daily.
More severe lower respiratory tract infections, or if pneumonia is suspected: 500 mg twice daily.
Pyelonephritis: 250 mg twice daily.
Uncomplicated gonorrhea: single dose of 1 g.
Oral suspension: Lyme disease in adults and children over the age of 12 years: 500 mg twice daily for 20 days.
Capsule and Tablet: Sequential therapy: Pneumonia: 1.5 g cefuroxime injection (cefuroxime sodium)/Vaxcel Cefuroxime twice daily (given i.v. or i.m.) for 48 to 72 hours, followed by 500 mg twice daily Axcel Cefuroxime Tablet (cefuroxime axetil) oral therapy for 7 to 10 days.
Acute exacerbations of chronic bronchitis: 750 mg cefuroxime injection (cefuroxime sodium)/Vaxcel Cefuroxime twice daily (given i.v. or i.m.) for 48 to 72 hours, followed by 500 mg twice daily Axcel Cefuroxime Tablet (cefuroxime axetil) oral therapy for 5 to 10 days. Duration of both parenteral and oral therapy is determined by the severity of the infection and the clinical status of the patient.
Dosage in children: Most infections: The usual dose is 125 mg twice daily or 10 mg/kg twice daily to a maximum of 250 mg daily.
For otitis media, in children less than 2 years of age, the usual dosage is 125 mg twice daily or 10 mg/kg bd to a maximum of 250 mg daily and in children over 2 years of age, 250 mg twice daily or 15 mg/kg twice daily to a maximum of 500 mg daily.
There is no experience or clinical trial data available on the use in children under 3 months of age.
Capsule: Elderly and patients with renal impairment: No special precautions are necessary in patients with renal impairment or on renal dialysis or in the elderly at dosages up to the normal maximum of 1 g per day. The usual course of therapy is seven days. Axcel Cefuroxime-250 Capsule should be taken after food for optimum absorption.
Oral suspension: Direction for mixing: Shake bottle well to loosen granules. Remove cap and Dose-Master adapter. Then, add some water to mix with the granules. After that, shake and top up to 50 ml mark. Place the Dose-Master adapter and cap. Shake the bottle well to mix the medicine properly.
Tablet: Renal impairment: Cefuroxime is primarily excreted by kidneys. In patients with markedly impaired renal function it is recommended that the dosage of cefuroxime be reduced to compensate for its slower excretion (see the table as follows). (See table.)
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