Neo-Penotran Forte Use In Pregnancy & Lactation

General Advice: Pregnancy category is C.
Women of child bearing potential/Birth Control (Contraception): Since the effects of active ingredients in NEO-PENOTRAN FORTE PESSARY for fetus and newborn growth are not clearly known, women who must use this product should avoid pregnancy with a proper birth control method.
Pregnancy: Preclinical studies on animals regarding the pregnancy, embryonal/fetal growth, perinatal and/or postnatal growth are insufficient. Potential risk for human is not known.
There is insufficient data regarding the use of NEO-PENOTRAN FORTE PESSARY in the first trimester of pregnancy. Therefore, NEO-PENOTRAN FORTE PESSARY should not be used in the first trimester of pregnancy. In the second and third trimesters, benefit/risk ratio should be evaluated by a physician, should not be used unless it is necessary.
Lactation: Breastfeeding should be discontinued, since metronidazole appears in milk. Breastfeeding can be started again 24-48 hours after the end of treatment.
Reproduction/Fertility: There is no evidence regarding hazardous effect on human and animal fertility when metronidazole or miconazole nitrate is administered alone.