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Patients should be advised not to take alcohol during the therapy and for 3 days after the end of the treatment, because of the possibility of a disulfiram-like reaction.
High doses and long term metronidazole may cause peripheral neuropathy and convulsion due to systemic usage.
Should not be used in virgins and in young people (girls) who are not sexually mature.
The ovules must not be used with contraceptive diaphragms and preservatives since the ovule base may react with the rubber.
Other vaginal products (e.g. tampon, douche or spermicide) should not be used concurrently during the treatment.
Sexual partners with Trichomonas vaginalis should be treated at the same time.
Effects on ability to drive and use machines: Systemic administration of metronidazole may affect driving and using machines. In comparison with systemic use, topical metronidazole is absorbed in vagina in low concentrations.
NEO-PENOTRAN FORTE PESSARY may cause dizziness, ataxia, fatigue and weakness, therefore may affect driving or operating machinery.
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