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When excessive amount of ovule is applied, systemic effects may occur due to metronidazole, but intravaginal metronidazole is not expected to cause life-threatening symptoms.
Symptomatic and supportive treatment should be instituted. There is no specific antidote for metronidazole. Cure can be provided in individuals who ingested a dose of 12 g of metronidazole.
Symptoms of metronidazole overdose are nausea, vomiting, abdominal pain, diarrhea, itching, metallic taste, ataxia, dizziness, paresthesia, convulsion, leukopenia, darkening of urine; symptoms of miconazole nitrate overdose are sore mouth and throat, anorexia, nausea, vomiting, headache, diarrhea.
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