Neo-Penotran Forte Dosage/Direction for Use

Posology/Frequency and duration of administration: One ovule should be inserted high into the vagina at night for 7 days.
In recurrent cases, application of one ovule at night for 14 days is recommended.
It is not recommended that the administration of NEO-PENOTRAN FORTE PESSARY in the menstrual period because of the impaired efficacy of the product or facing some difficulties during administration.
Method of Administration: Only for intravaginal use. NEO-PENOTRAN FORTE PESSARY should be applied in lying position, high into the vagina using.
Not to be swallowed or applied by other routes.
Additional information on special populations: Renal/Liver failure: In renal failure, the half-life of metronidazole is not changed. Therefore, dose reduction is not necessary but in serious impaired renal function which hemodialysis is required, dose adjustment should be done.
In serious liver function failures metronidazole clearance may be impaired. Metronidazole may increase encephalopathy symptoms due to increased plasma levels and therefore should be used carefully in hepatic encephalopathy patients.
Paediatric population: Not to be used in children under 18.
Geriatric population: No data.