NEO-PENOTRAN FORTE PESSARY should not be used: In patients known to be hypersensitive to the active ingredients or their derivatives; In patients using alcohol during the treatment or within 3 days after the treatment; In patients using disulfiram during the treatment or within 2 weeks; During the first trimester of pregnancy; In pregnant women who have trichomanal vaginitis in the first trimester; In cases of porphyria, epilepsy, serious liver function disorders.