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The concomitant application of adrenaline-containing eye drops may cause mydriasis.
Timolol's pharmacologic action of reducing intraocular pressure is enhanced by adrenaline- or pilocarpine-containing eye drops.
The concomitant systemic use of beta-blockers may lead to mutual increase in each drug's pharmacologic activity; intraocular pressure reduction by timolol will be enhanced as well as systemic beta-blocking activity on the cardiovascular system.
Hypotension and bradycardia may be potentiated by the concomitant use of timolol with oral calcium antagonist, digitalis, catecholamine-releasers or beta-blockers.
