Timo-COMOD 0.5% is contraindicated in patients with bronchial hyperreactivity; bronchial asthma; severe chronic obstructive pulmonary disease; sinus bradycardia; second and third degree atrio-ventricular block; overt cardiac failure; cardiogenic shock; hypersensitivity to any ingredient of this product; severe allergic rhinitis or nutritional disorders involving the cornea.