Timo-COMOD Adverse Reactions

For the assessment of side effects the following frequencies of occurrence are defined: Very common: more than 1 of 10 treated patients; Common: more than 1 of 100 treated patients; Uncommon: more than 1 of 1000 treated patients; Rare: more than 1 of 10 000 treated patients; Very rare: 1 or less than 1 of 10 000 treated patients, including single cases.
Eyes: Very rarely, irritations of the eyes, such as conjunctivitis, blepharitis, keratitis, impaired vision, diplopia, ptosis and sensation of dryness of the eyes.
Systemic side-effects: Cardiovascular system: Very rarely, bradycardia, arrhythmia, hypotension, syncopes, atrioventricular block, cerebrovascular insult, cerebral ischemia, heart failure, cardiac arrest and palpitations.
Respiratory system: Very rarely, bronchospasm (especially in patients with existing bronchospastic disease), respiratory insufficiency and dyspnea.
Skin: Very rarely, hypersensitivities, such as local or general exanthemas, urticaria and individual cases alopecia.
Other side-effects: Very rarely, headache, weakness, vomiting, giddiness and depression.
Advice: Like in every treatment of glaucoma, the intraocular pressure as well as the cornea should be examined regularly.
Contact lenses should be removed before before applying the eye drops and should be reinserted 15 minutes after application the earliest.