Retrokor Special Precautions

Prior to administration, susceptibility to Retrokor should be tested to prevent manifestation of resistant bacteria and the duration of treatment should be the minimum needed for the treatment. A patient should be asked about his/her condition in order to predict reaction eg, shock and also his previous skin reaction should be tested.
First aid should be prepared: In case of anaphylactic shock, epinephrine should be injected IV and then glucocorticoid should be administered. After administration, the patient should be observed in the stable state. Regular clinical tests eg, liver, renal, hematologic tests should be performed.
Shadows mistaken for gallstone have been observed in ultrasonography of gall bladder of patients administered with higher than recommended dosage of Retrokor. However, termination of administration cleared the shadows which are precipitates of calcium ceftriaxone. Termination of therapy should be determined by a clinician.
In overdosage, concentrations of Retrokor would not be reduced by hemodialysis or peritoneal dialysis. There is no specific antidote. Symptomatic treatment should be performed.
Patients with a history of allergy to drugs.
Patients whose family are susceptible to cause the allergy symptoms eg, bronchial asthma, eruption and urticaria.
Patients with severe renal disorder. Because the plasma concentration is maintained, the drug should be administered by reduced-dose or prolonged administration interval.
Patients who cannot ingest orally or parenteral patients, elderly, patients with poor systemic condition. Patients should be sufficiently observed because avitaminosis K may occur.
Effects on the Ability to Drive or Operate Machinery: There is no report that Retrokor inhibited the patient's driving or operating machinery.
Use in pregnancy & lactation: Since use in pregnancy has not been established, ceftriaxone should be used only when the expected benefits clearly outweigh the potential risks.
Caution should be observed in administration to nursing mothers since a small amount of Retrokor has been distributed in human milk.
Use in children: Safe use in neonates and prematures has not been established. In vitro studies have shown that ceftriaxone, like some other cephalosporins, can displace bilirubin from serum albumin. Ceftriaxone (Retrokor) should not be administered to hyperbilirubinemic neonates especially prematures.