Retrokor Dosage/Direction for Use

Adults and children >12 years: Usual Dose: 1-2 g, once daily, IV or IM. The total daily dose may increase up to 4 g depending on the type and severity of infection.
Neonates: Usual Dose: 25-50 mg/kg body weight once daily in neonates (within 14 days of age). The total daily dose should not exceed 50 mg/kg body weight.
The dosage in neonates does not have to differentiate between premature and mature babies.
Neonates and children 15 days to 12 years: Usual Dose: 20-80 mg/kg body weight once daily.
Children weighing 50 kg should receive the usual adult dosage of ceftriaxone. In IV administration of >50 mg/kg body weight, Retrokor should be administered for at least 30 min by intermittent IV injection.
Elderly: Usual adult dosage of ceftriaxone should be given.
Meningitis: Initial dose for neonates and children is 100 mg/kg body weight once daily. The total daily dose should not exceed 4 g.
Dosages may be decreased immediately when pathogen and sensitivity of infection or organism are clarified. The following duration of therapy has been shown effective: Neisseria meningitidis, 4 days; Haemophilus influenzae, 6 days; Streptococcus pneumococcus, 7 days.
Gonorrhea: For the treatment of gonorrhea caused by penicillin-susceptible and -resistant organisms, the dose is 250 mg once IM.
Prophylaxis of Perioperative Infections: A single dose of 1-2 g administered 30-90 min before surgery is recommended in order to prevent postoperative infections in surgical operations which was contaminated or have potential to contaminate. In colorectum operation, the administration of Retrokor with 5-nitroimidazole (eg, ornidazole) respectively, separately, simultaneously is effective.
Renal or Hepatic Disorder: If the liver function of the patient with renal disorder is normal, the dosage does not have to be decreased but if the patient is in the terminal stages of kidney failure with 10 mL/min of creatinine clearance, the daily dose should not exceed 2 g.
In patients with hepatic disorder whose renal function is normal, the dosage does not have to be decreased. In the case of severe renal or hepatic failure, serum concentration should be regularly monitored. In dialysis patients, the additional administration after dialysis is not necessary, however, because the excretion rate of dialysis patients may be reduced, serum concentration should be monitored to determine dosage control.
Duration of Therapy: The duration of therapy depends on the type and severity of infection. Generally, therapy should be continued for at least 48-72 hrs after the patient becomes asymptomatic or evidence of the infection has been obtained.
Preparation of Solution: IM Injection: 0.25 and 5 g of Retrokor should be reconstituted in 2 mL of 1% lidocaine HCl; 1 g of Retrokor in 3.5 mL 1% lidocaine HCl. Reconstituted solution should be administered into hips. More than 1 g should not be administered on side of the hips. Pain appears if lidocaine HCl solution is not used in IM. Lidocaine solution should not be administered IV.
IV Injection: 0.25 or 0.5 g of Retrokor should be reconstituted in 5 mL water for injection and 1 g Retrokor in 10 mL water for injection. The reconstituted solution should be slowly injected for 2-4 min IV. Intermittent IV infusion should be continued at least 30 min. 2 g of Retrokor should be dissolved in 40 mL of one of the following solutions not containing calcium: Saline injection; mixture solution of 0.45% sodium chloride and 2.5, 5 or 10% dextrose injection; 5% dextrose injection containing 6% dextran solution, 6-10% hydroxyethyl starch solution or water for injection.
Ceftriaxone solutions should not be physically mixed with or piggybacked into solutions containing other antimicrobial drugs or into diluent solutions other than those mentioned previously due to possible incompatibility. Reconstituted solution is stable for 6 hrs at room temperature or for 24 hrs at 5°C, physically and chemically, however, the solution should be used immediately after preparation. Discard any remaining portion. The color of the solution varies from pale yellow to yellowish brown according to the concentration and storage period.