Retrokor Drug Interactions

Concomitant administration with similar compounds (other cephem-series compounds) and diuretics eg, furosemide may increase renal impairment.
In vitro studies with gram-negative Bacillus indicates that the antibacterial activity of ceftriaxone and aminoglycosides may be additive or synergistic against some strains of Pseudomonas aeruginosa. This is important in the severe symptoms by pathogens eg, Bacillus procyaneous or in the life-threatening infection. Concomitant administration of both aminoglycosides and ceftriaxone are contraindicated. Both should be administered alone within the recommended dose. There is no evidence that ceftriaxone increases the renal toxicity of aminoglycosides.
A disulfiram-like reaction reportedly occurred in a patient who ingested alcohol while receiving ceftriaxone.
Concomitant administration of probenecid does not appear to affect excretion of ceftriaxone.
Retrokor has no N-methylthiotetrazole side chain relating to intolerance and bleeding against ethanol in the administration of other cephalosporins.
In test tube test, concomitant administration with chloramphenicol resulted to antagonism.
Clinical Tests: Pseudopositive reflex may develop in urinary glucose determination using Benedict's solution, Fehling's solution; Clinitest except Tes-Tape reaction. Positive Coombs' test may occur. Pseudopositive response may develop in the galactosemia test as with other antibiotics.