Hypersensitivity: If rash, urticaria, erythema, ruber, pruritus, chill, flush, allergic dermatitis, edema, erythema multiforme, anaphylactic or anaphylactoid reactions occur, the administration should be discontinued and/or appropriate therapy should be initiated.
Hematologic: Occasionally, agranulocytosis, eosinophilia, thrombocythemia may occur. Rarely, anemia, hemolytic anemia, thrombocytopenia, prothrombin disorder may occur.
Hepatic: Occasionally, elevations of GOT, GPT, AL-P and the symptom by precipitation of ceftriaxone calcium salt in cholecyst may occur. Rarely, elevations of bilirubin, γ-GTP may occur.
Renal: Rare cases of severe renal disorder including acute kidney failure have been reported. It should therefore be monitored regularly. If any symptoms occur, the administration should be discontinued and/or appropriate therapy should be instituted.
Gastrointestinal: Rarely, severe colitis accompanying with hemofecia of pseudomembranous colitis may occur. If aneilema, frequent diarrhea occur, an appropriate therapy should be instituted or discontinue administration. Occasionally, nausea; vomiting; loose stool, diarrhea or rarely, aneilema, anorexia may also occur.
Respiratory: In the administration of other cephem-series antibiotics, interstitial pneumonia accompanied by flush, cough, dyspnea, abnormal chest X-ray, eosinophilia and PIE syndrome may occur rarely. If the symptoms occur, administration should be discontinued and/or appropriate therapy including the administration of adrenocortical hormone should be instituted.
Superinfection: Rarely, stomatitis, candidiasis may occur.
Avitaminosis: Rarely, avitaminosis K (eg, hypoprothrombinemia, bleeding tendency) and avitaminosis B group (eg, glossitis, stomatitis, anorexia, neuritis) may occur.
Others: Occasionally, headache or edema, precipitation in cholecyst, ventricular extrasystole may occur.
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