Medzyme/Medzyme Vial Special Precautions

Medzyme: History of hypersensitivity to penicillin, and GI disease (particularly colitis). Renal impairment. Pregnancy and lactation.
Medzyme Vial: Careful inquiry should be made concerning previous allergic reactions of the patient to cephalosporins, penicillins and other drugs prior to initiation of cefuroxime therapy.
Dosage of cefuroxime should be reduced in patients with transient or persistent renal insufficiency because high and prolonged serum antibiotic concentrations can occur in such in individuals given usual doses.
Prolonged use of cefuroxime may result in the over-growth of non-susceptible organisms. Careful observation of the patient is therefore essential. If severe super-infection occurs during therapy, the drug treatment should be interrupted.
Pseudomembranous colitis has been reported with the use of broad-spectrum antibiotics, one primary cause is Clostridium difficile, and therefore, it is important to consider this diagnosis and to treat with metronidazole patients who develop severe diarrhea in association with the use of antibiotics. Broad-spectrum antibiotics should therefore also be prescribed with extra caution in individuals with a history of gastro-intestinal disease, particularly colitis.
Effects on ability to drive and operate machines: The drug does not affect ability to drive and operate machines.