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Medzyme: Probenecid reduces the renal clearance of cefuroxime.
Medzyme Vial: Used concurrently, furosemide-diuretics or aminoglycoside antibiotics may increase renal disorder. Thus, in such cases, carefully monitor renal function, particularly, for the aged and the patients with a history of renal impairment.
High-dose probenecid decreases cefuroxime renal clearance, giving rise to higher and more prolonged plasma concentrations of cefuroxime.
