A fine tremor of skeletal muscle which occurs in some patients; usually the hands are most obviously affected.
Small increase in heart rate may occur.
Adverse effects of salbutamol are CNS stimulation, malaise, emotional lability, fatigue, nightmares, aggressive behavior, lightheadedness, disturbed sleep, irritability, bronchitis, nasal congestion, sputum increase, epistaxis, hoarseness, increased appetite, stomachache, muscle cramps, pallor, conjunctivitis, anorexia, teeth discoloration, dyspepsia, dilated pupils, epigastric pain, micturition difficulty, muscle spasm, voice changes, urticaria, angioedema, rash, bronchospasm, oropharyngeal edema, erythema multiforme, and Stevens-Johnson syndrome have been associated with the administration of salbutamol sulfate syrup in children.
Guaifenesin is well tolerated and has a wide margin of safety. Products containing guaiphenesin have been associated with nausea, vomiting, GI discomfort, dizziness, headache, skin rash, and urticaria.