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Symptoms: Overdosage of oral salbutamol produces symptoms that are mainly extensions of common adverse effects. In addition to exaggeration of common adverse effects, angina, hypertension, and hypokalemia have occurred following overdosage.
Overdosage with guaiphenesin is unlikely to produce toxic effects since its toxicity is low. Guaifenesin, when administered by stomach tube to test animals in doses up to 5 g/kg, produced no signs of toxicity.
Treatment: In the management of salbutamol overdosage, a relatively selective beta 1-adrenergic blocking agent (e.g., metoprolol tartrate) may be used, if necessary, but only with extreme caution on asthmatic attack may be induced. Dialysis is not appropriate therapy for the management of salbutamol overdosage.
In severe cases of overdosage with guaiphenesin, treatment should be aimed at reducing further absorption of the drug. Gastric emptying (emesis or gastric lavage) is recommended as soon as possible after ingestion. Treatment is symptomatic and supportive.
