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Beta blockers: Concomitant use with salbutamol may inhibit cardiac, bronchodilating and vasodilating effects.
Severe bronchospasm may be produced in asthmatic patients taking salbutamol. Consider cardioselective beta blockers, and use with caution if there are no alternatives to beta blocker therapy.
Diuretics: ECG changes and hypokalemia associated with these diuretics may worsen with coadministration.
Digoxin: Digoxin serum levels may be decreased.
Drug/Lab test interactions: Guaifenesin may increase renal clearance for urate and thereby lower serum uric acid levels. Guaifenesin may produce an increase in urinary 5-hydroxyindoleacetic (5-HIAA) acid and may therefore interfere with the interpretation of this test for the diagnosis of carcinoid syndrome. It may also falsely elevate the vanillylmandelic acid (VMA) test for catechols. Administration of this drug should be discontinued 48 hours prior to the collection of urine specimens for such tests.
