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Alcohol: A disulfiram-like reaction, which is characterised primarily by flushing of the face, neck and arms may occur with any of the sulphonylureas when alcohol is ingested concurrently. The risk of hypoglycaemia may be increased or prolonged when moderate or large amounts of alcohol have been consumed concurrently with sulphonylurea antidiabetic agents.
Anticoagulants (coumarin- or indandione derivative) will increase their anticoagulant and hypoglycaemic effects.
Potentiation of the hypoglycaemic action of gliclazide may occur with the concomitant administration of sulphonamides, salicylates, phenylbutazone, β-adrenoreceptor-blocking agents, MAOIs, ketoconazole and miconazole. Diminution of hypoglycaemic action of gliclazide may occur with the concomitant administration of thiazide diuretics, corticosteroids and oestrogens.
