Gliclazide should not be used in insulin-dependent diabetes, pregnancy, diabetics complicated by ketosis and acidosis, diabetics undergoing surgery, diabetic coma, diabetic pre-coma, hyperosmolar nonketotic coma, after severe burns or trauma or during infections and patients known to have hypersensitivity to other sulphonylureas and related drugs. It is also contraindicated in severe renal and hepatic insufficiency.
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