Pharmaniaga Gliclazide Adverse Reactions

Gastrointestinal disturbances such as nausea, vomiting, heartburn, anorexia, diarrhoea and a metallic taste may occur with sulphonylureas and are usually mild and dose-dependent. Increased appetite and weight gain may occur. Skin rashes and pruritus may occur and photosensitivity has been reported. Rashes are usually hypersensitivity reactions and may progress to more serious disorders. Hypoglycaemia occurs with all hypoglycaemic agents.
Other severe effects may be manifestations of a hypersensitivity reaction. They include cholestatic jaundice, leucopenia, thrombocytopenia, aplastic anaemia, agranulocytosis, haemolytic anaemia, erythema multiforme or the Stevens-Johnson syndrome, exfoliative dermatitis and erythema nodosum.
The sulphonylureas may infrequently induce a syndrome of inappropriate secretion of antidiuretic hormone (SIADH) characterised by water retention, hyponatraemia and central nervous system effects.