Symptoms and Treatment of Overdose: Symptoms of overdosage include diarrhoea, nausea with or without vomiting, abdominal pain, drowsiness, dizziness, nervousness, headache, blurred vision. Mefenamic Acid has a marked tendency to induce tonic-clonic (grand mal) convulsions in overdosage. Dyskinesia, acute renal failure and coma have been reported. Overdose has led to fatalities. Treatment is symptomatic and supportive. The stomach should be emptied by inducing emesis or by careful gastric lavage followed by the administration of activated charcoal. Vital functions should be monitored and supported. Because Mefenamic Acid and its metabolites are firmly bound to plasma proteins, hemodialysis and peritoneal dialysis may be of little value.
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