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Pharmacology: Pharmacodynamics: It is a nonsteroidal agent with demonstrated anti-inflammatory, analgesic and antipyretic activity. In animal studies, it was found to inhibit prostaglandin synthesis and to compete for binding at the prostaglandin receptor site. Its exact mode of action is not known.
Pharmacokinetics: Following a single one gram oral dose, peak plasma level of 10 mcg/ml occurred in 2 to 4 hours with a half-life of 2 hours. Following multiple doses, plasma levels are proportional to dose with no evidence of drug accumulation. One gram of Mefenamic Acid given four times daily produces peak blood level of 20 mcg/ml by the second day of administration. Following a single dose, sixty-seven percent of the total dose is excreted in the urine as unchanged drug or as one of two metabolites. Twenty to twenty-five percent of the dose is excreted in the faeces during the first three days.
