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Mefenamic Acid should not be used in patients who have previously exhibited hypersensitivity to it. Because the potential exists for cross-sensitivity to aspirin or other NSAIDs, Mefenamic Acid should not be given to patients in whom these drugs induce symptoms of bronchospasm, allergic rhinitis or urticaria.
Mefenamic Acid is contraindicated in patients with active ulceration or chronic inflammation of either the upper or lower gastrointestinal tract.
Mefenamic Acid should be avoided in patients with pre-existing renal disease. Since Mefenamic Acid is eliminated primarily by the kidneys, the drug should not be administered to patients with significantly impaired renal function.
