Thiogamma I.V. Overdosage

Symptoms: In case of overdose, nausea, vomiting and headache may occur. After accidental or suicidal ingestion of oral doses of 10-40 g of thioctic acid in combination with alcohol, severe intoxication has been reported, in some cases with fatal outcome. Initially, clinical intoxication can present as psychomotor agitation or clouding of consciousness. Later, typical symptoms such as generalized seizures and lactic acidosis may develop. In addition, hypoglycemia, shock, rhabdomyolysis, hemolysis, disseminated intravascular coagulation (DIC), bone marrow depression, and multiple organ dysfunction were described after the use of high doses of thioctic acid.
Therapy: At the slightest suspicion of an intoxication, immediate hospitalisation is required and the treating institution's standard procedures for cases of poisoning should be initiated.
Treatment of generalized seizures, lactic acidosis and other life-threatening consequences of intoxication must follow the principles of modern intensive care and must be based on the symptoms. Currently, there is no evidence that haemodialysis, haemoperfusion or filtration methods for forced elimination of thioctic acid are appropriate for mitigating the symptoms of intoxication.