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Pregnancy: Progesterone is used to support embryo implantation and maintain pregnancy as a component of assisted reproductive technology (ART) treatment in infertile women. Such use is associated with increased ongoing pregnancy rates.
There have also been reports of congenital malformations, including limb reduction defects, neural tube defects, and congenital heart malformations, after intra-uterine exposure to progestogen in early pregnancy. However, many analyses of accumulated data have found no evidence of a recognisable malformation syndrome.
Lactation: Progesterone is excreted in breast milk. Administration is not therefore recommended in women who are breastfeeding.
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