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Food: Concomitant food ingestion increased the bioavailability of Micronised Progesterone Capsules.
Drug: Enzyme-inducing drugs such as carbamazepine, griseofulvin, phenobarbital, phenytoin, and rifampicin may enhance the clearance of progesterone and the progestogens.
The metabolism of progesterone by human liver microsomes was inhibited by ketoconazole (IC50 <0.1 μM). Ketoconazole and other inhibitors of CYP450-3A4 such as ritonavir and nelfinavir may increase bioavailability of progesterone.
Laboratory tests: Progesterone may affect the results of laboratory tests of hepatic and/or endocrine functions.
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