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Should be used with extreme caution in patients who have impaired liver function, cardiovascular disease, chronic respiratory disorders, gastric ulcer, aggravation of preexisting ulcer has been reported.
Zycloran may intensify the effects of alcohol and CNS depressants. Use cautiously in patients with a history of seizures since the drug tends to lower the seizure threshold. It may impair sensitivity and adaptation to changes of environmental temperature so that fatal hyperthermia and heat stroke are possible complications.
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