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Pharmacology: Pharmacokinetics: Doxycycline is 90% to almost 100% absorbed in the gastrointestinal tract after oral administration, not much affected by milk and food. It is widely distributed in the body tissues and fluids. Plasma half-life is the longest of the tetracyclines, namely, 12 to 24 hours which accounts for its slow rate of excretion (25% to 40%).
Doxycycline is excreted slowly in the urine in patients with normal renal function. However, the majority of a dose of doxycycline is excreted in the feces after chelation in the intestines. It does not accumulate significantly in patients with renal impairment.
