The absorption of Doxycycline is reduced by divalent and trivalent cations such as aluminum, bismuth, calcium, iron, magnesium and zinc and therefore, concomitant administration of tetracyclines with antacids, iron preparations, some foods such as milk and dairy products or other preparations containing such cations, whether as active ingredients or excipients may result in subtherapeutic serum concentrations of the antibacterial. Sodium bicarbonate, colestipol and kaolin-pectin will also reduce its absorption. Its nephrotoxic effects may be exacerbated by diuretics, methoxyflurane or other potentially nephrotoxic drugs.
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