Adult 200 mg as single dose on 1st day or 100 mg repeated after 12 hr followed by 100 mg daily. Childn >8 yr weighing ≤45 kg Initially 4 mg/kg in 2 divided doses followed by 2 mg/kg daily. Patient w/ sensitive gonococcal infections 300 mg as single dose or followed by a 2nd similar dose 1 hr later. Patient w/ syphilis 200 or 300 mg daily for at least 14 or 10 days respectively. Acne 50 mg daily. Relapsing fever & louse-borne typhus 100 or 200 mg as a single dose. Prophylaxis of scrub typhus 200 mg as a single dose. Prophylaxis of leptospirosis 200 mg once every 7 days. Should be initiated 1-2 days before & throughout exposure.
Oesophageal ulceration if taken w/ insufficient fluid or in recumbent posture. May cause permanent teeth discoloration in childn. Pregnancy & lactation.
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