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Neomycin, streptomycin, polymyxin B, 2-phenoxyethanol, and formaldehyde are used in the production of this vaccine.
Although purification procedures eliminate measurable amounts of these substances, traces may be present and allergic reactions may occur in persons sensitive to these substances.
Systemic adverse reactions reported in infants receiving IPV concomitantly at separate sites or combined with DTP have been similar to those associated with administration of DTP alone. Local reactions are usually mild and transient in nature.
Although no causal relationship between Inactivated Poliomyelitis Vaccine (Types 1, 2 and 3) and Guillain-Barré Syndrome (GBS) has been established, GBS has been temporally related to administration of another Inactivated Poliomyelitis Vaccine (Types 1, 2 and 3). Deaths have been reported in temporal association with the administration of IPV.
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