Sign Out
PHARMACOLOGY: Poliomyelitis is caused by poliovirus Types 1, 2 and 3. It is primarily spread by the fecal-oral route of transmission but may also be spread by the pharyngeal route.
Approximately 90% to 95% of poliovirus infections are asymptomatic. Nonspecific illness with low-grade fever and sore throat (minor illness) occurs in 4% to 8% of infections. Aseptic meningitis occurs in 1% to 5% of patients a few days after the minor illness has resolved. Rapid onset of asymmetric acute flaccid paralysis occurs in 0.1% to 2% of infections, and residual paralytic disease involving motor neurons (paralytic poliomyelitis) occurs in approximately 1 per 1,000 infections.
Inactivated Poliomyelitis Vaccine (Types 1, 2 and 3) induces the production of neutralizing antibodies against each type of virus which are related to protective efficacy.
Continue with Google