The most frequently reported side effects are reactions at the site of injection: pain, erythema, induration and systemic reactions like moderate transient fever. Other side effects are oedema that can occur within 48 hours and persist for one or two days, lymphadenopathy, hypersensitivity reaction (urticaria, Quincke's oedema) in response to one of the vaccine components. Anaphylactic reactions occur very rarely. The other reactions are moderate and transient arthralgia and myalgia, convulsions, headaches, moderate and transient paresthesia occurring in the two days following vaccination.