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Pregnancy: Animal studies by the oral route have shown reproductive toxicity at high systemic exposure. There have been reports of birth defects among babies born to woman exposed to topical retinoids during pregnancy. Due to the limited available data and because a very weak cutaneous passage of adapalene is possible, this product should not be used in woman of childbearing age, unless an effective means of contraception is used. In case of unexpected pregnancy, treatment should be discontinued.
Breast-feeding: No study on animal or human milk transfer was conducted after cutaneous application of Adapalene. No effects on the suckling child are anticipated since the systemic exposure of the breast-feeding woman to Adapalene is negligible. Adapalene can be used during breastfeeding. To avoid contact exposure of the infant, application of Adapalene to the chest should be avoided when used during breast-feeding.
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