Klenzit-MS Drug Interactions

There are no known interactions with other medications which might be used cutaneously and concurrently with Adapalene Gel microsphere; however, other retinoids or drugs with a similar mode of action should not be used concurrently with adapalene.
Adapalene is essentially stable to oxygen and light and is chemically non-reactive. Whilst extensive studies in animals and man have shown neither phototoxic nor photoallergic potential for adapalene, the safety of using adapalene during repeated exposure to sunlight or UV irradiation has not been established in either animals or man. Exposure to excessive sunlight or UV irradiation should be avoided. It is advisable to use sunscreen before stepping out in the sunlight. Patients, who normally experience high level of sun exposure, and those with inherent sensitivity to sun, should be warned to exercise caution.
Absorption of adapalene through human skin is low (see Pharmacology: Pharmacokinetics under Actions) and therefore interaction with systemic medications is unlikely. There is no evidence that the efficacy of oral drugs such as contraceptives and antibiotics is influenced by the cutaneous use of Adapalene Gel microsphere.
Adapalene Gel has a potential for mild local irritation, and therefore it is possible that concomitant use of peeling agents, abrasive cleansers, strong drying agents, astringents or irritant products (aromatic and alcoholic agents) may produce additive irritant effects. However, cutaneous antiacne treatment (e.g. erythromycin up to 4%) or clindamycin phosphate (1% as the base) solutions or benzoyl peroxide water based gels up to 10% may be used in the morning when Adapalene Gel microsphere is used at night as there is no mutual degradation or cumulative irritation.
Particular caution should be exercised in using preparations containing sulfur, resorcinol or salicylic acid in combination with Adapalene Gel microsphere. If these preparations have been used, it is advisable not to start therapy with Adapalene Gel microsphere, until the effects of such preparations in the skin have subsided.