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Adapalene Gel microsphere is not to be taken orally and is for cutaneous use only. If the medication is applied excessively, no more rapid or better results will be obtained and marked redness, peeling or discomfort may occur.
The acute oral dose of Adapalene Gel microsphere required to produce toxic effects in mice is greater than 10 mg/kg. Nevertheless, unless the amount accidentally ingested is small, an appropriate method of gastric emptying should be considered.
Chronic ingestion of the drug may lead to the same side effects as those associated with excessive oral intake of Vitamin A.
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