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Beta-blocking agent may mask the symptoms of hypoglycemia. Some of the drugs leading to reduced insulin requirement: Oral hypoglycemic agents. octreotide, monoamine oxidase inhibitor, nonselective β-blocking agents, angiotensin-converting enzyme inhibitors, salicylates, alcohol and alcohol steroids.
Some of the drugs leading to increase insulin requirement: Oral contraceptives, thiazides, glucocorticoids, thyroid hormones and sympathomimetics, danazol.
Incompatibilities: In general terms, insulin should only be added to compounds with which it is known to be compatible. Insulin suspensions should not be added in infusion fluids.
