Insuget R/Insuget N/Insuget 70/30 Dosage/Direction for Use

The type of formulation, its dose and the frequency of administration should be determined by the physician, according to the needs suitable to the patient. The dose should be adjusted as necessary according to the results of regular monitoring of glucose concentrations in the blood glucose (or occasionally urine concentrations). A total dose in excess of about 80 units daily would be unusual and may indicate the presence of a form of insulin resistance.
The average daily requirement for diabetes therapy ranges between 0.5 IU/kg and 0.1 IU/kg, depending on the individual needs of the patient. Optimized metabolic control, including glucose monitoring, is therefore recommended during insulin treatment.
Elderly: The primary aim of treatment may be relief of symptoms and avoidance of hypoglycemic events.
Insuget R: May be taken 1-4 times daily, before meals and possibly at bedtime. Regular or rapid-acting insulin should be administered 30-45 min before a meal. It can be mixed in the same syringe with intermediate-acting insulins, but in such situations, the regular insulin is drawn first. Insuget R should be given by SC injection but may, although not recommended, also be given by IM injection. It may also be administered IV. Insuget R is administered SC into the thigh or abdominal wall. If convenient, the gluteal or deltoid region may be used.
Insuget N (NPH): Administered SC into the thigh or abdominal wall, preferably before meals, 1-2 times daily depending upon the requirement of the individual. If convenient, the gluteal or deltoid region may be used. It should be administered about 30 min before a meal. It can also be mixed in the same syringe with short-acting soluble insulins, and in such situations, the regular insulin is drawn first. Insuget N (NPH) cannot be given IV.
Insuget 70/30: A premixed insulin is usually given once or twice daily, preferably just before meals when rapid initial effect together with a more prolonged effect is desired.
Ketoacidosis: Only Insuget R should be used. Treatment includes adequate fluid replacement, usually by infusing sodium chloride 0.9% initially and the administration of potassium salts to prevent or correct hypokalemia. Insulin should be given by continuous IV infusion if possible, although other routes have also been used. Insulin can also be given by IM injection.
Adults: Initial loading dose of 20 units is followed by 6 units every hour until the blood glucose concentration falls to 10 mmol/L, when the dose is given every 2 hrs.
Since insulin normally corrects hyperglycemia before ketosis, it is usually necessary to continue administration of insulin once normoglycemia has been achieved but to change the rehydration fluid to glucose-saline so that the additional glucose prevents the development of hypoglycemia.
Administration: Shake well before use.
Pinch the skin between 2 fingers, push the needle into the skinfold and inject the insulin under the skin.
Keep the needle under the skin for at least 6 sec to make sure all the insulin has been injected.
If blood appears after the needle has been withdrawn, press the injection site lightly with a finger.