Severe hypoglycemia may lead to unconsciousness and may result in temporary or permanent impairment of brain function or even death.
Weight gain is common when taking insulin.
Edema and refraction anomalies may occur upon initiation of insulin therapy. Local hypersensitivity reactions (redness, swelling and itching at the injection site) are those transitory reactions, which may occur during the treatment with insulin and normally disappear during continued treatment.
Lipodystrophy may occur at the injection site as a consequence of failure to rotate injection site within an area.
Generalized hypersensitivity reactions may occur occasionally and can cause generalized skin rash, itching, sweating, gastrointestinal upset, angioneurotic edema, difficulties in breathing, palpitation and reduction in blood pressure. These are potentially life-threatening.
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