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Photosensitivity manifested by an exaggerated sunburn reaction has been observed in some individuals taking tetracycline. Patients apt to be exposed to direct sunlight or ultraviolet light should be advised that this reaction can occur with tetracycline drugs and treatment should be discontinued at the first evidence of skin erythema.
As with other tetracyclines, this drug forms a stable calcium complex in any bone-forming tissue. A decrease in the fibula growth rate has been observed in prematures given oral Tetracycline in dose 25 mg/kg every 6 hours. This reaction was shown to be reversible when the drug was discontinued. The anti-anabolic action of the tetracycline may cause an increase in BUN, Doxycycline rarely gives rise to increased urea concentration in renal failure.
