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As with other antibiotics, use of this drug may result in overgrowth of non-susceptible organisms, including fungi. If super infection occurs, appropriate therapy should be instituted.
In venereal diseases when coexistent syphilis is suspected, dark field examination should be done before treatment is started and the blood serology repeated monthly for at least 4 months.
Because the tetracyclines have been shown to depress plasma prothrombin activity, patients who are on anticoagulant therapy may require downward adjustment of their anticoagulant dosage.
In long term therapy, periodic laboratory evaluation of organ systems, including hematopoietic, renal and hepatic studies should be performed.
All infections due to Group A beta-hemolytic streptococci should be treated for at least 10 days to decrease the likelihood of rheumatic fever or acute glomerulonephritis.
Since the bacteriostatic drugs may interfere with the bactericidal action of penicillin, it is advisable to avoid giving tetracycline in conjunction with penicillin.
Use in Children: The drug should not be used in children below 8 years old. (See CONTRAINDICATIONS).
