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Absorption of tetracyclines is impaired by antacids containing aluminum, calcium, or magnesium, zinc and iron-containing preparations.
Bismuth subsalicylate may impair doxycycline absorption.
Concomitant therapy of tetracycline with anticoagulants may result to prolongation of prothrombin time. Reduction of dose may be necessary.
Bacteriostatic drugs may interfere with the bactericidal action of penicillin and aminoglycosides.
Concomitant use of barbiturates, carbamazepine, phenytoin and other hepatic enzyme inducers may decrease the serum half-life of doxycycline.
Doxycycline may decrease efficacy of contraceptives.
Drug/Laboratory Test Interactions: False elevations of urinary catecholamine levels may occur due to interference with the fluorescence test.
