Biogesic For Kids

Paracetamol (Biogesic) 100 mg/mL Syrup (Oral Drops), 120 mg/5 mL Syrup, and 250 mg/5 mL Syrup (Orange Flavor): An orange-colored, clear syrup with an orange odor and taste.
Paracetamol (Biogesic) 120 mg/5 mL Syrup, and 250 mg/5 mL Syrup (Melon Flavor): An orange-colored, clear syrup with a melon odor and taste.
Each mL suspension (oral drops) contains: Paracetamol 100 mg.
Each 5 mL suspension contains: Paracetamol 120 mg or 250 mg.
These products use the TasteRite technology of PediaTech. The TasteRite technology is a unique taste-masking system developed specifically for liquid dosage forms.
This technology significantly reduces the bitterness of medicine so that children taste the flavor and not the medicine.
In addition, these products use Tooth Friendly technology TFTech to significantly reduce or eliminate enamel loss that leads to tooth decay.

Analgesic/Antipyretic (Anilide).
These products contain paracetamol, a fever reducer and pain reliever.

See Table 1.

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General Recommendations: Infants and children should not exceed 5 doses in each 24-hour period.
Leave at least 4 hours between doses.
Do not use continuously for more than 5 days at a time unless directed by a doctor.
Do not use more than the recommended dose.
Avoid potential liver damage by giving lower doses of paracetamol in patients classified under the lower body weight group.
This medicine should be taken orally every 4 to 6 hours, as needed for pain and/or fever, or, as directed by a doctor.
Dosing in Children: 10 mg/kg body weight per dose given every 4 to 6 hours, as needed; or, the patient can follow the dose in the dosing table as follows: See Table 2.

Click on icon to see table/diagram/image
 
What Should the Patient Do if They Miss a Dose: If the patient misses a dose, take the next dose if still needed for pain and/or fever and the subsequent doses every 4 to 6 hours thereafter.
Do not double the dose.

Overdosage of paracetamol usually involves four phases with the following signs and symptoms: Reduced or loss of appetite, nausea, vomiting, malaise (a general feeling of being unwell), and excessive sweating.
Right upper abdominal pain or tenderness, liver enlargement which may be characterized by abdominal discomfort of "feeling full", elevated bilirubin and liver enzyme concentrations, prolongation of prothrombin time, and occasionally decreased urine output.
Reduced or loss of appetite, nausea, vomiting, and malaise recur (usually 3 to 5 days after initial symptom onset); signs of liver failure (e.g., jaundice, hypoglycemia, coagulopathy, encephalopathy), and possibly kidney failure and cardiomyopathy (disorder of the heart muscle) may develop.
Recovery or progression to fatal complete liver failure.
Metabolic acidosis (excessive acid in the body), encephalopathy (abnormal brain function), coma, and death may also occur. Clinical and laboratory evidence of hepatic toxicity may not be apparent 48 to 72 hours post-ingestion, and reach a maximum after 4 to 6 days.
What to Do When the Patient Has Taken More Than the Recommended Dosage: If the patient has taken more than the recommended dosage, consult a doctor or contact a poison control center right away, even if the patient seems well, as there is a risk of delayed serious liver damage. Quick medical attention is important for adults as well as for children even if the patient does not notice any signs or symptoms.

If the patient is allergic to paracetamol or any ingredient of the product.
If the patient is taking other medicines that contain paracetamol.

Care to be taken when taking this medicine: Liver Warning: This product contains paracetamol. Severe liver damage may occur if: A child takes more than 5 doses in 24 hours, which is the maximum daily amount; An adult or child 12 years old and above takes more than 4 g of paracetamol in 24 hours; Taken with other medicines containing paracetamol (or acetaminophen).
Allergy alert: Paracetamol may cause allergic reactions. Symptoms may include: Skin redness; Blisters; Skin rash or hives; Swelling of the face, tongue or throat; Difficulty swallowing; Unexplained wheezing or shortness of breath.
Ask a doctor before use if patient has liver or kidney disease.
Use with caution in patients with glucose-6-phosphate dehydrogenase deficiency (G6PD), a hereditary condition which can lead to decreased blood cell count and possible hemolytic anemia (anemia resulting from destruction of red blood cells).
Do not take more than the recommended dose.
Ask a doctor before use if: The patient has kidney or liver problems (including alcoholic liver disease).
The patient is taking other pain killers or any other medicines (see Interactions).
The patient has G6PD deficiency.
The cause of the patient's illness is not clear or it is accompanied by a rash, breathing difficulties, diarrhea or excessive tiredness or lethargy.
The patient is severely malnourished, anorexic, have a low body mass index (underweight), or excessively drinks alcohol.
Stop use and ask a doctor if: If symptoms of allergic reaction occur, (such as skin redness, blisters, or rash), stop use and seek medical help right away (see Care to be taken when taking this medicine as previously mentioned).
Symptoms worsen or do not improve.
New symptoms occur.
Any undesirable effect occurs.
Redness or swelling is present.
Fever gets worse or lasts more than 3 days.
Pain gets worse or lasts more than 5 days in children (<12 years old) and 10 days in adults.
Patient had unexpected bruising or bleeding, and had more infections than usual.
Consult a doctor promptly if sore throat is severe, persists for more than 2 days, is accompanied or followed by fever, headache, rash, nausea, or vomiting.

Paracetamol, when taken within the recommended dose and duration of treatment, has low incidence of side effects.
Blood and lymphatic system disorders: Anemia (decreased number of healthy red blood cells), changes in the number of white blood cells and platelets such as agranulocytosis (decrease in the number of granulocytes), leukopenia (decrease in the number of leukocytes), methemoglobinemia (presence of methemoglobin in the blood), neutropenia (decrease in the number of neutrophils), pancytopenia (deficiency of all cellular elements in the blood), thrombocytopenia (decrease in the number of platelets); thrombocytopenic purpura (small purple-red marks in the skin or other tissue caused by low number of platelets).
Immune system disorders: Allergic reactions (some are life-threatening) which may cause difficulty swallowing, unexplained wheezing, shortness of breath or difficulty in breathing, skin rash, hives, or angioedema (swelling of face, tongue, lips, or throat); proneness to infections, swelling around the eyes.
Metabolism and nutrition disorders: Hyperchloremia (increased chlorine ion in the blood), hyperuricemia (increased uric acid in the blood), loss of appetite, metabolic acidosis (too much acid in the body), sudden weight loss.
Nervous system disorders: Headache.
Vascular disorders: Unusual bleeding or bruising.
Respiratory, thoracic, and mediastinal disorders: Respiratory distress (noisy, congested breathing), runny nose, laryngeal edema (swelling of the voice box).
Gastrointestinal disorders: Mouth ulcers, nausea, sore throat, vomiting.
Skin and subcutaneous tissue disorder: Fixed eruption (an allergic reaction described as well-defined, round or oval patches of redness and swelling in skin that recurs in the same site each time a particular drug is taken), itchy rash, severe skin reactions (i.e., Stevens-Johnson syndrome, toxic epidermal necrolysis, and acute generalized exanthematous pustulosis) which may include symptoms such as skin redness, blisters, rash, itching, and peeling of the upper surface of the skin.
Hepatobiliary disorders: Chronic hepatic necrosis (death of liver tissues) in prolonged use, liver dysfunction, liver injury, yellowing of eyes and skin.
Renal and urinary disorders: Kidney toxicity, papillary necrosis in prolonged use.
General disorders and administration site conditions: Fatigue or unusual tiredness.
Investigations: Decreased serum bicarbonate, serum calcium, serum sodium; increases in serum alkaline phosphatase, serum glucose, and transaminase levels.

Do not use with any other medicine containing paracetamol (prescription or nonprescription). If the patient is not sure whether a medicine contains paracetamol, ask a doctor.
Prolonged use of paracetamol with other painkillers [e.g., drugs called nonsteroidal anti-inflammatory drugs (NSAIDs), aspirin] is not recommended since it may increase the risk of toxic effects to the kidneys and eventually of kidney failure.
Chronic intake of alcohol may increase the risk of paracetamol-induced liver toxicity. Acute intake of alcohol may diminish the ability of the body to metabolize large doses of paracetamol. It is advised to consult a doctor before intake of paracetamol.
The absorption of paracetamol may be increased by metoclopramide or domperidone. Cholestyramine, narcotic pain relievers, and some antidepressants that slow down gastric emptying reduce the absorption of paracetamol. If the patient is taking these medicines, talk to the doctor first before taking paracetamol.
Medicines which stimulate the enzymes responsible for the metabolic activation of paracetamol such as medicines for convulsion (e.g., phenobarbital), depression (e.g., tricyclic antidepressants), and oral contraceptives may reduce the efficacy of paracetamol and increase susceptibility to the harmful effects to the liver.
Phenothiazines (medicines for serious mental and emotional disorder) may increase the risk of severe hypothermia (abnormally low body temperature).
Paracetamol increases exposure to chloramphenicol. This interaction should be considered when both medicines are given together in malnourished patients.
Probenecid may affect the elimination of paracetamol.
There may be an increased risk of bleeding when using paracetamol and warfarin (a blood thinning medicine) at the same time. Paracetamol, especially its prolonged regular use, increases the blood thinning effect of warfarin and other coumarins. If the patient is taking warfarin, ask the doctor first before taking paracetamol.
Tell the doctor if the patient is taking other medicines (especially other paracetamol-containing medicines), including vitamins, supplements, and herbal medicines.

Store at temperatures not exceeding 30°C.
For oral drops: Do not refrigerate.

Analgesics (Non-Opioid) & Antipyretics

N02BE01 - paracetamol ; Belongs to the class of anilide preparations. Used to relieve pain and fever.

Non-Rx