Blood and lymphatic system disorders: Anemia (decreased number of healthy red blood cells), changes in the number of white blood cells and platelets such as agranulocytosis (decrease in the number of granulocytes), leukopenia (decrease in the number of leukocytes), methemoglobinemia (presence of methemoglobin in the blood), neutropenia (decrease in the number of neutrophils), pancytopenia (deficiency of all cellular elements in the blood), thrombocytopenia (decrease in the number of platelets); thrombocytopenic purpura (small purple-red marks in the skin or other tissue caused by low number of platelets).
Immune system disorders: Allergic reactions (some are life-threatening) which may cause difficulty swallowing, unexplained wheezing, shortness of breath or difficulty in breathing, skin rash, hives, or angioedema (swelling of face, tongue, lips, or throat); proneness to infections, swelling around the eyes.
Metabolism and nutrition disorders: Hyperchloremia (increased chlorine ion in the blood), hyperuricemia (increased uric acid in the blood), loss of appetite, metabolic acidosis (too much acid in the body), sudden weight loss.
Nervous system disorders: Headache.
Vascular disorders: Unusual bleeding or bruising.
Respiratory, thoracic, and mediastinal disorders: Respiratory distress (noisy, congested breathing), runny nose, laryngeal edema (swelling of the voice box).
Gastrointestinal disorders: Mouth ulcers, nausea, sore throat, vomiting.
Skin and subcutaneous tissue disorder: Fixed eruption (an allergic reaction described as well-defined, round or oval patches of redness and swelling in skin that recurs in the same site each time a particular drug is taken), itchy rash, severe skin reactions (i.e., Stevens-Johnson syndrome, toxic epidermal necrolysis, and acute generalized exanthematous pustulosis) which may include symptoms such as skin redness, blisters, rash, itching, and peeling of the upper surface of the skin.
Hepatobiliary disorders: Chronic hepatic necrosis (death of liver tissues) in prolonged use, liver dysfunction, liver injury, yellowing of eyes and skin.
Renal and urinary disorders: Kidney toxicity, papillary necrosis in prolonged use.
General disorders and administration site conditions: Fatigue or unusual tiredness.
Investigations: Decreased serum bicarbonate, serum calcium, serum sodium; increases in serum alkaline phosphatase, serum glucose, and transaminase levels.
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