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APLOSYN preparations are virtually non-sensitizing and non-irritating.
General precautions and limitations: Although side effects are not ordinarily encountered with topically applied corticosteroids, as with all drugs, a few patients may react unfavorably under certain conditions. If reactions or idiosyncrasies are encountered, the agent should be discontinued and appropriate steps taken.
Occlusive dressing method, precautions and limitations. If occlusion of total body or extensive areas is employed, the possibility of systematic absorption of the corticosteroids being used exists and suitable precautions should be taken. For patients with extensive disease it may be preferable to use a sequential approach, treating one portion of the body at a time. Occasionally, patients may shown contact sensitivity to a particular dressing material or adhesive. In such instances, a substitute occlusive dressing material or adhesive should be employed, or the technique discontinued. Malodor, which may be observed upon removal of closed dressing, will usually disappear with simple washing. The lesions should be carefully inspected between dressing to determine whether infection is developing. On infrequent occasions, miliaria, folliculitis, or pyodermas have been seen with the use of this technique. The development of infection requires appropriate local or systematic antibacterial therapy and discontinuation of the occlusive dressing method. Malodor and infection however, both decrease in incidence if dressing is renewed every 24 hours.
In the management of the psoriatic patient, it has been observed that the patient whose disease is in a chronic stabilized phase is the best candidate. While lesion relapses can be expected to occur in most patients upon discontinuation of topical corticosteroid therapy, remissions may persist for several weeks to several months in favorable cases. The patient whose psoriasis is in an active stage, with recent appearance of new lesions may not be a good candidate, and may show very early relapse of lesions, relative resistance to topical corticosteroid, or development of new lesions.
Some plastic films may be flammable and due care should be exercised in their use. Similarly, caution should be employed when such films are used on children or left their proximity, to avoid the possibility of accidental suffocation.
