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Fluocinolone (Aplosyn) are intended for topical use in acute and chronic dermatoses.
APLOSYN-10 CREAM for occlusive dressing therapy, maintenance therapy and for pediatric cases; specifically for wet lesions.
A. Maintenance therapy: The 0.01% Cream is particularly useful in maintenance therapy of large areas in the indications listed above.
B. Occlusive dressing therapy: Closed dressings applied over APLOSYN have been found effective for the management of a number of particularly stubborn chronic dermatoses. These include psoriasis, chronic dermatitis, lichen planus, lichen simplex chronicus, granuloma annulare. Fluocinolone acetonide (Aplosyn) – 10 Cream is sparingly applied to the lesion and gently rubbed in until it disappears. The cream is reapplied, leaving a thin coating over the lesion. This area is then completely covered with a pliable non-porous film such as Sarah Wrap, polyethylene, or a similar material. Frequency of dressing change is best determined on an individual basis. It may be changed, twice daily or once daily, but as a general rule, change of dressing every 24 hours is recommended. Convenience may dictate the use of closed dressings for only part of each day, with the use of bland emollients between dressings for dry, fissured lesions. In general, the rate of response of a given lesion is directly related to the total time the lesion is treated with the closed dressing. In general, the rate of response of a given lesion is directly related to the total time lesion is treated with the closed dressing. Reapplication of fluocinolone acetonide (Aplosyn) in the method given above is essential at each change of dressing. Improvement is noted in three to four days and complete remission, except for residual erythema, usually occurs in one to three weeks.
For those lesions which are essentially dry, it is important that the dressing be made as airtight and watertight as possible. The edges of the covering film preferably are sealed to adjacent normal skin with an adhesive material, thus preventing evaporation. In some instances, it may be advisable to initially increase local water content by briefly soaking the lesion before application. For those lesions which are essentially moist, especially those of the eczematous dermatitis group, complete sealing of the lesion may not be needed. Here, the covering plastic film is useful to keep the medication in place over the lesion and to retain some water, but incomplete sealing of the edges of the film or punctures in the film will allow excess moisture to escape. Patients with eczematous dermatitis may be particularly prone to develop irritation with the use of adhesive materials; hence, it may be preferable to hold the dressings in place with gauze or elastic bandages, stockings, etc. For use in pediatric patients.
APLOSYN-10 OINTMENT for pediatric use, maintenance therapy, occlusive therapy; specifically for dry lesions. This is most suitable when emollient and water protective effect is desired.
APLOSYN-25 CREAM: Topical application is indicated in the following areas of therapy: Atopic dermatitis, neurodermatitis, contact dermatitis, seborrheic dermatitis, eczematous dermatitis, pruritus ani, lichen planus, post-anal surgery, nummular eczema, stasis dermatitis, intertrigo, exfoliative dermatitis, intertriginous psoriasis. A small amount should be applied lightly to the affected area two or three times daily, as needed. The cream should be massaged gently and thoroughly until it disappears. Since the Cream is in a water – washable, vanishing cream base, it is easily applied and leaves no traces. APLOSYN may be used over long periods of time in specific conditions when deemed necessary.
APLOSYN-25 OINTMENT is most suitable when an emollient and water protective effect is desired, as in atopic dermatitis where there is a tendency to fissuring and cracking, in hand dermatoses and during cold weather.
Advantages: Speedy remission of chronic dermatoses when other topical corticosteroids have failed.
Has a very high anti-inflammatory activity.
Effective in sparing amounts and easily applied.
No systemic effects on routine topical application.
