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Pharmacology: Pharmacodynamics and Pharmacokinetics: Fluocinolone acetonide (Aplosyn) is a synthetic anti-inflammatory corticosteroid that produces vasoconstriction and suppression of membrane permeability, mitotic activity, immune response and release of inflammatory mediators in the body.
Independently of the route of administration, the systemic absorption of Fluocinolone acetonide (Aplosyn) is below 0.1 ng/ml which indicates that the systemic distribution is very minimal and the effect of fluocinolone is mainly local. Following absorption, fluocinolone acetonide (Aplosyn) metabolism is primarily hepatic. The reported half-life of fluocinolone acetonide ranges between 1.3-1.7 hours. Fluocinolone acetonide (Aplosyn) is mainly excreted by the kidneys. Volume of distribution, protein binding and clearance are not relevant as the systemic absorption of Fluocinolone acetonide (Aplosyn) is very minimal and the concentration in urine is lower than the minimum quantitation limit.
