There is no well documented experience with Amlodipine overdosage. Since absorption of Amlodipine is slow, gastric lavage should be performed. Available data suggests that the gross overdosage could result in excessive peripheral vasodilation with subsequent marked and probably prolonged hypotension, which calls for active cardiovascular support including monitoring of cardiac and respiratory function, elevation of extremities, attention to circulating fluid volume and urine output. Intravenous calcium gluconate may help to reverse the effects of calcium entry blockade. A vasoconstrictor agent may be helpful in restoring vascular tone and blood pressure provided there is no contraindication to its use. Since Amlodipine is highly protein bound, dialysis is unlikely to be of benefit.